Article
Toward precision medicine in glioblastoma: the promise and the challenges.
Neuro-oncology - 1 Aug 2015
Prados Michael D, Byron Sara A, Tran Nhan L, Phillips Joanna J, Molinaro Annette M, Ligon Keith L, Wen Patrick Y, Kuhn John G, Mellinghoff Ingo K, de Groot John F, Colman Howard, Cloughesy Timothy F, Chang Susan M, Ryken Timothy C, Tembe Waibhav D, Kiefer Jeffrey A, Berens Michael E, Craig David W, Carpten John D, Trent Jeffrey M
Abstract excerpt
Integrated sequencing strategies have provided a broader understanding of the genomic landscape and molecular classifications of multiple cancer types and have identified various therapeutic opportunities across cancer subsets. Despite pivotal advances in the characterization of genomic alterations in glioblastoma, targeted agents have shown minimal efficacy in clinical trials to date, and patient survival...
Topics
- Antineoplastic Agents
- Brain Neoplasms
- Clinical Trials as Topic
- Glioblastoma
- Humans
- Molecular Targeted Therapy
- Mutation
- Precision Medicine