Article
Signatures of accelerated somatic evolution in gene promoters in multiple cancer types.
Nucleic acids research - 23 Jun 2015
Smith Kyle S, Yadav Vinod K, Pedersen Brent S, Shaknovich Rita, Geraci Mark W, Pollard Katherine S, De Subhajyoti
Abstract excerpt
Cancer-associated somatic mutations outside protein-coding regions remain largely unexplored. Analyses of the TERT locus have indicated that non-coding regulatory mutations can be more frequent than previously suspected and play important roles in oncogenesis. Using a computational method called SASE-hunter, developed here, we identified a novel signature of accelerated somatic evolution (SASE) marked by a...
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