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Article

Colorectal Carcinogenesis: Connecting K-RAS-Induced Transformation and CREB Activity In Vitro and In Vivo.

Molecular cancer research : MCR - 1 Aug 2015

Steven André, Heiduk Max, Recktenwald Christian V, Hiebl Bernhard, Wickenhauser Claudia, Massa Chiara, Seliger Barbara

Abstract excerpt

UNLABELLED: Oncogenic transformation is often associated with an increased expression of the cAMP response element binding (CREB) transcription factor controlling the expression of genes involved in cell proliferation, cell cycle, apoptosis, and tumor development, but a link between K-RAS(V12)-induced transformation and CREB has not yet been determined. Therefore, the constitutive and/or inhibitor-regulated mRNA...

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Source

Identifiers

PMID: 25934695
DOI: 10.1158/1541-7786.MCR-14-0590

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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