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Article

The induction of S100p expression by the Prostaglandin E₂ (PGE₂)/EP4 receptor signaling pathway in colon cancer cells.

Cancer biology & therapy - 15 Nov 2010

Chandramouli Anupama, Mercado-Pimentel Melania E, Hutchinson Anthony, Gibadulinová Adriana, Olson Erik R, Dickinson Sally, Shañas Reneé, Davenport Jennifer, Owens Janae, Bhattacharyya Achyut K, Regan John W, Pastorekova Silvia, Arumugam Thiruvengadam, Logsdon Craig D, Nelson Mark A

Abstract excerpt

BACKGROUND: Prostaglandin E₂ (PGE₂) levels are frequently elevated in colorectal carcinomas. PGE₂ is perceived via four transmembrane G protein coupled receptors (EP1-4), among which the EP4 receptor is most relevant. PGE₂/EP4-receptor interaction activates CREB via the ERK/MEK pathway. However,...

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Identifiers

PMID: 20890108
DOI: 10.4161/cbt.10.10.13373
PMCID: PMC3047097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20890108-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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