Progressive cognitive impairment and anxiety induction in the absence of plaque deposition in C57BL/6 inbred mice expressing transgenic amyloid precursor protein.

Abstract excerpt

Numerous transgenic mouse models for Alzheimer's disease (AD) have been generated to recapitulate the histological pathogenesis and behavioral phenotypes of AD brain. However, none of the existing models exhibits the full spectrum of AD symptoms, nor have all of the traits mimicked by the developed animal models been successfully represented within a single mouse line, indicating that the development of...

Topics

• Alzheimer Disease
• Amyloid beta-Protein Precursor
• Analysis of Variance
• Animals
• Anxiety
• Avoidance Learning
• Behavior, Animal
• Blotting, Northern
• Blotting, Western
• Cognition Disorders