Article
Toll-Like Receptor 4 Gene Polymorphism C1196T in Polish Women with Postmenopausal Osteoporosis - Preliminary Investigation.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Jan 2000
Kaleta Beata, Walicka Magdalena, Sawicka Ada, Bogołowska-Stieblich Agata, Górski Andrzej, Łukaszkiewicz Jacek, Marcinowska-Suchowierska Ewa
Abstract excerpt
BACKGROUND: Postmenopausal osteoporosis is a systemic bone disease characterized by low bone mass after menopause. Bone remodeling is regulated by a number of factors, including the immune system. Toll-like receptors 4 (TLR4) are expressed on bone cells and modify the immune response. TLR4 gene polymorphism may take part in the development of chronic inflammation in women after menopause, which is the cause of...
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