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Can Polymorphisms in NLRP3 Inflammasome Complex Be Associated with Postmenopausal Osteoporosis Severity?

Genes - 2 Dec 2022

Guaraná Werbson Lima, Lima Camilla Albertina Dantas, Barbosa Alexandre Domingues, Crovella Sergio, Sandrin-Garcia Paula

Abstract excerpt

The immune system plays a critical role in bone homeostasis and, consequently, in the pathophysiology of postmenopausal osteoporosis (OP) since estrogen deficiency induces the inflammasome and increases production of pro-inflammatory cytokines, such as IL-1β and IL-18. NLRP3 inflammasome complex genes have been related with bone homeostasis in cellular and animal models. Here, we performed an association study...

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Source

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Identifiers

PMID: 36553538
DOI: 10.3390/genes13122271
PMCID: PMC9777825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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