Article
Takayasu arteritis and ulcerative colitis: high rate of co-occurrence and genetic overlap.
Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2015
Terao Chikashi, Matsumura Takayoshi, Yoshifuji Hajime, Kirino Yohei, Maejima Yasuhiro, Nakaoka Yoshikazu, Takahashi Meiko, Amiya Eisuke, Tamura Natsuko, Nakajima Toshiki, Origuchi Tomoki, Horita Tetsuya, Matsukura Mitsuru, Kochi Yuta, Ogimoto Akiyoshi, Yamamoto Motohisa, Takahashi Hiroki, Nakayamada Shingo, Saito Kazuyoshi, Wada Yoko, Narita Ichiei, Kawaguchi Yasushi, Yamanaka Hisashi, Ohmura Koichiro, Atsumi Tatsuya, Tanemoto Kazuo, Miyata Tetsuro, Kuwana Masataka, Komuro Issei, Tabara Yasuharu, Ueda Atsuhisa, Isobe Mitsuaki, Mimori Tsuneyo, Matsuda Fumihiko
Abstract excerpt
OBJECTIVE: Takayasu arteritis (TAK) is a systemic vasculitis affecting large arteries and large branches of the aorta. Ulcerative colitis (UC) is a prevalent autoimmune colitis. Since TAK and UC share HLA-B*52:01 and IL12B as genetic determinants, and since there are case reports of the co-occurrence of these diseases, we hypothesized that UC is a common complication of TAK. We undertook this study to perform a...
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