Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Colorectal carcinomas with KRAS codon 12 mutation are associated with more advanced tumor stages.

BMC cancer - 1 May 2015

Li Wenbin, Qiu Tian, Zhi Wenxue, Shi Susheng, Zou Shuangmei, Ling Yun, Shan Ling, Ying Jianming, Lu Ning

Abstract excerpt

BACKGROUND: KRAS mutation occurs in 35%-40% of colorectal cancer (CRC). The aim of our study was to evaluate the pathological and molecular features of specific KRAS mutated colorectal carcinomas. KRAS and BRAF (V600E) mutation tests were performed in 762 primary tumors from a consecutive cohort study of Chinese CRC patients. METHODS: DNA mismatch repair (MMR) status was determined by immunohistochemistry (IHC)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Mutation

Share to Neoplasm Staging

Share to Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25929517
DOI: 10.1186/s12885-015-1345-3
PMCID: PMC4423107

Genes

KRAS
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Colorectal carcinomas with KRAS codon 12 mutation are associated with more advanced tumor stages.PMID 25929517Read ↗

Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type colorectal cancers.Semantic proximity Read ↗

BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients.Semantic proximity Read ↗

Detection of KRAS mutations and their associations with clinicopathological features and survival in Chinese colorectal cancer patients.Semantic proximity Read ↗

KRAS codon 12 and 13 mutations in relation to disease-free survival in BRAF-wild-type stage III colon cancers from an adjuvant chemotherapy trial (N0147 alliance).Semantic proximity Read ↗

Association Between Specific Mutations in KRAS Codon 12 and Colorectal Liver Metastasis.Semantic proximity Read ↗

Clinical characteristics and prognostic value of the KRAS mutation in Chinese colorectal cancer patients.Semantic proximity Read ↗

Prognostic Value of KRAS Mutations in Colorectal Cancer PatientsSemantic proximity Read ↗

KRAS codon 12 and 13 mutations may guide the selection of irinotecan or oxaliplatin in first-line treatment of metastatic colorectal cancer.Semantic proximity Read ↗

KRAS Codon 12 Mutation is Associated with More Aggressive Invasiveness in Synchronous Metastatic Colorectal Cancer (mCRC): Retrospective ResearchSemantic proximity Read ↗

Specific mutations in KRAS codon 12 are associated with worse overall survival in patients with advanced and recurrent colorectal cancer.Semantic proximity Read ↗

KRAS exon 2 codon 13 mutation is associated with a better prognosis than codon 12 mutation following lung metastasectomy in colorectal cancer.Semantic proximity Read ↗

A Systematic Review and Meta-analysis on the Occurrence of Biomarker Mutation in Colorectal Cancer among the Asian Population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.