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Article

Colorectal carcinomas with KRAS codon 12 mutation are associated with more advanced tumor stages.

BMC cancer - 1 May 2015

Li Wenbin, Qiu Tian, Zhi Wenxue, Shi Susheng, Zou Shuangmei, Ling Yun, Shan Ling, Ying Jianming, Lu Ning

Abstract excerpt

BACKGROUND: KRAS mutation occurs in 35%-40% of colorectal cancer (CRC). The aim of our study was to evaluate the pathological and molecular features of specific KRAS mutated colorectal carcinomas. KRAS and BRAF (V600E) mutation tests were performed in 762 primary tumors from a consecutive cohort...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Codon
Colorectal Neoplasms
DNA Mismatch Repair
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Staging

Proto-Oncogene Proteins

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25929517
DOI: 10.1186/s12885-015-1345-3
PMCID: PMC4423107

Genes

KRAS
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-25929517-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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