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Human HAD phosphatases: structure, mechanism, and roles in health and disease

21 May 2012

Abstract excerpt

Phosphatases of the haloacid dehalogenase (HAD) superfamily of hydrolases are an ancient and very large class of enzymes that have evolved to dephosphorylate a wide range of low- and high molecular weight substrates with often exquisite specificities. HAD phosphatases constitute approximately one-fifth of all human phosphatase catalytic subunits. While the overall sequence similarity between HAD phosphatases is...

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PMID: 22607316
DOI: 10.1111/j.1742-4658.2012.08633.x

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