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Article

Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage.

Bioorganic chemistry - 1 Dec 2006

Lahiri Sushmita D, Zhang Guofeng, Dunaway-Mariano Debra, Allen Karen N

Abstract excerpt

Phosphonatase functions in the 2-aminoethylphosphonate (AEP) degradation pathway of bacteria, catalyzing the hydrolysis of the C-P bond in phosphonoacetaldehyde (Pald) via formation of a bi-covalent Lys53ethylenamine/Asp12 aspartylphosphate intermediate. Because phosphonatase is a member of the haloacid dehalogenase superfamily, a family predominantly comprised of phosphatases, the question arises as to how this...

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Identifiers

PMID: 17070898
DOI: 10.1016/j.bioorg.2006.09.007
PMCID: PMC1941675

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