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The mutation landscape of multiple cancer predisposition genes in Chinese familial/hereditary breast cancer families.

Cancer biology & medicine - 28 Sept 2021

Dong Li, Zhang Hailian, Zhang Huan, Ye Yingnan, Cheng Yanan, Li Lijuan, Wei Lijuan, Han Lei, Cao Yandong, Li Shixia, Hao Xishan, Liu Juntian, Yu Jinpu

Abstract excerpt

OBJECTIVE: Approximately 5%-10% of breast cancer (BC) patients display familial traits that are genetically inherited among the members of a family. The purpose of this study was to profile the germline mutations in 43 genes with different penetration rates and their correlations with phenotypic traits in Chinese familial BC families. METHODS: Ion Torrent S5™-based next generation sequencing was conducted on 116...

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Breast Neoplasms
China
Genetic Predisposition to Disease
Mutation

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PMID: 34570441
DOI: 10.20892/j.issn.2095-3941.2021.0011
PMCID: PMC9257317

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