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Fibronectin Matrix Assembly Suppresses Dispersal of Glioblastoma Cells

30 Sept 2011

Abstract excerpt

Glioblastoma (GBM), the most aggressive and most common form of primary brain tumor, has a median survival of 12-15 months. Surgical excision, radiation and chemotherapy are rarely curative since tumor cells broadly disperse within the brain. Preventing dispersal could be of therapeutic benefit. Previous studies have reported that increased cell-cell cohesion can markedly reduce invasion by discouraging cell...

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PMID: 21980357
DOI: 10.1371/journal.pone.0024810

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