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Apolipoprotein E genotype modulates effects of vitamin B12 and homocysteine on grey matter volume in Alzheimer's disease.

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society - 1 Jan 2016

Lee Young-Min, Ha Ji-Kyung, Park Je-Min, Lee Byung-Dae, Moon EunSoo, Chung Young-In, Kim Ji-Hoon, Kim Hak-Jin, Mun Chi-Woong, Kim Tae-Hyung, Kim Young-Hoon

Abstract excerpt

AIMS: The aim of the present study was to investigate whether the effects of vitamin B12 and homocysteine on brain volume are influenced by apolipoprotein E (APOE) genotype. We examined the effects in each subgroup (APOE ε4 carriers and non-carriers) of Alzheimer's disease (AD) patients and healthy normal controls. METHODS: Forty participants with AD and 20 healthy normal controls were recruited from memory...

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Identifiers

PMID: 25919635
DOI: 10.1111/psyg.12109

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APOE

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