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Article

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

7 Apr 2011

Abstract excerpt

The tumor microenvironment strongly influences cancer development, progression, and metastasis. The role of carcinoma-associated fibroblasts (CAFs) in these processes and their clinical impact has not been studied systematically in non-small cell lung carcinoma (NSCLC). We established primary cultures of CAFs and matched normal fibroblasts (NFs) from 15 resected NSCLC. We demonstrate that CAFs have greater...

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PMID: 21474781
DOI: 10.1073/pnas.1014506108

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