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Cancer cell – Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma

2 Aug 2024

Abstract excerpt

Interactions between cells in the tumor microenvironment (TME) shape cancer progression and patient prognosis. To gain insights into how the TME influences cancer outcomes, we derive gene expression signatures indicative of signaling between stromal fibroblasts and cancer cells, and demonstrate their prognostic significance in multiple and independent squamous cell carcinoma cohorts. By leveraging information...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39262776
DOI: 10.1016/j.isci.2024.110635

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