Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension

Abstract excerpt

RATIONALE: Pulmonary arterial hypertension (PAH) is a serious lung condition characterized by vascular remodeling in the precapillary pulmonary arterioles. We and others have demonstrated chromosomal abnormalities and increased DNA damage in PAH lung vascular cells, but their timing and role in disease pathogenesis is unknown. OBJECTIVES: We hypothesized that if DNA damage predates PAH, it might be an intrinsic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chemotherapy-induced cardiotoxicity and mitigation
• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Share to Pulmonary Hypertension Research and Treatments