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DNA Damage and Repair in Pulmonary Arterial Hypertension

19 Oct 2020

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a complex multifactorial disease with both genetic and environmental dynamics contributing to disease progression. Over the last decade, several studies have demonstrated the presence of genomic instability and increased levels of DNA damage in PAH lung vascular cells, which contribute to their pathogenic apoptosis-resistant and proliferating characteristics. In addition,...

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PMID: 33086628
DOI: 10.3390/genes11101224

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