Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension.

American journal of respiratory and critical care medicine - 1 Nov 2010

Aldred Micheala A, Comhair Suzy A, Varella-Garcia Marileila, Asosingh Kewal, Xu Weiling, Noon George P, Thistlethwaite Patricia A, Tuder Rubin M, Erzurum Serpil C, Geraci Mark W, Coldren Christopher D

Abstract excerpt

RATIONALE: Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Previous studies have indicated that the endothelial cell proliferation is quasineoplastic, with evidence of monoclonality and instability of short DNA microsatellite sequences. OBJECTIVES: To assess whether there is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Airway Remodeling
Share to Bone Morphogenetic Protein Receptors, Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

Share to Microarray Analysis

Share to Myocytes, Smooth Muscle

Share to Pulmonary Artery

Share to Pulmonary Disease, Chronic Obstructive

Share to X Chromosome Inactivation

Source

Open in PubMed Open full text

Identifiers

PMID: 20581168
DOI: 10.1164/rccm.201003-0491OC
PMCID: PMC3001257

Genes

PAH
BMPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension.PMID 20581168Read ↗

DNA methylation signatures of pulmonary arterial smooth muscle cells in chronic thromboembolic pulmonary hypertensionSemantic proximity Read ↗

Loss of bone morphogenetic protein receptor 2 is associated with abnormal DNA repair in pulmonary arterial hypertension.Semantic proximity Read ↗

SNPs array karyotyping reveals a novel recurrent 20p13 amplification in primary myelofibrosis.Semantic proximity Read ↗

Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension.Semantic proximity Read ↗

Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic ApproachSemantic proximity Read ↗

Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension.Semantic proximity Read ↗

BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension.Semantic proximity Read ↗

Germline and Somatic Mutations in DNA Methyltransferase 3A<i>(DNMT3A)</i>Predispose to Pulmonary Arterial Hypertension (PAH) in Humans and Mice:<i>Implications for Associated PAH</i>Semantic proximity Read ↗

Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension.Semantic proximity Read ↗

Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation.Semantic proximity Read ↗

Clonality of smooth muscle and fibroblast cell populations isolated from human fibroid and myometrial tissuesSemantic proximity Read ↗

Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial HypertensionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.