Article
Inconsistency and features of single nucleotide variants detected in whole exome sequencing versus transcriptome sequencing: A case study in lung cancer.
Methods (San Diego, Calif.) - 15 Jul 2015
O'Brien Timothy D, Jia Peilin, Xia Junfeng, Saxena Uma, Jin Hailing, Vuong Huy, Kim Pora, Wang Qingguo, Aryee Martin J, Mino-Kenudson Mari, Engelman Jeffrey A, Le Long P, Iafrate A John, Heist Rebecca S, Pao William, Zhao Zhongming
Abstract excerpt
Whole exome sequencing (WES) and RNA sequencing (RNA-Seq) are two main platforms used for next-generation sequencing (NGS). While WES is primarily for DNA variant discovery and RNA-Seq is mainly for measurement of gene expression, both can be used for detection of genetic variants, especially single nucleotide variants (SNVs). How consistently variants can be detected from WES and RNA-Seq has not been...
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