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Searching for a Cell-Based Therapeutic Tool for Haemophilia A within the Embryonic/Foetal Liver and the Aorta-Gonads-Mesonephros Region.

Thrombosis and haemostasis - 1 Aug 2018

Serrano Luis J, Cañete Ana, Garcia-Leal Tamara, Tomás-Gallardo Laura, Flores Ana I, de la Torre Paz, Liras Antonio, Sánchez María José

Abstract excerpt

The development of new strategies based on cell therapy approaches to correct haemophilia A (HA) requires further insights into new cell populations capable of producing coagulation factor VIII (FVIII) and presenting stable engraftment potential. The major producers of FVIII in the adult are liver sinusoidal endothelial cells (LSECs) and in a lesser degree bone marrow-derived cells, both of which have been shown...

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PMID: 29991091
DOI: 10.1055/s-0038-1661351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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