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Article

Use of global assays to understand clinical phenotype in congenital factor VII deficiency.

Haemophilia : the official journal of the World Federation of Hemophilia - 1 Sept 2013

Greene L A, Goldenberg N A, Simpson M L, Villalobos-Menuey E, Bombardier C, Acharya S S, Santiago-Borrero P J, Cambara A, DiMichele D M

Abstract excerpt

Congenital factor VII (FVII) deficiency is characterized by genotypic variability and phenotypic heterogeneity. Traditional screening and factor assays are unable to reliably predict clinical bleeding phenotype and guide haemorrhage prevention strategy. Global assays of coagulation and fibrinolysis may better characterize overall haemostatic balance and aid in haemorrhagic risk assessment. We evaluated the...

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PMID: 23682803
DOI: 10.1111/hae.12160

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