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Article

Emergence and Rising Prevalence of Artemisinin Partial Resistance Marker Kelch13 P441L in a Low Malaria Transmission Setting in Southern Zambia.

The Journal of infectious diseases - 15 Oct 2025

Martin Anne C, Sadler Jacob M, Simkin Alfred, Musonda Michael, Katowa Ben, Matoba Japhet, Schue Jessica, Simulundu Edgar, Bailey Jeffrey A, Moss William J, Juliano Jonathan J, Fola Abebe A

Abstract excerpt

Increasing artemisinin partial resistance (ART-R) due to mutations in the gene encoding Kelch13 (Pfk13) protein in eastern Africa is of urgent concern, and mutations, such as Pfk13 P441L, continue to emerge. We used an amplicon deep-sequencing panel to estimate the prevalence of validated and candidate ART-R Pfk13 mutations in samples collected between 2018 and 2023 in southern Zambia. Pfk13 P441L was present in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40241390
DOI: 10.1093/infdis/jiaf188
PMCID: PMC12526945

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