Article
Substantial proliferation of human renal tubular epithelial cell-reactive CD4+CD28null memory T cells, which is resistant to tacrolimus and everolimus.
Transplantation - 15 Jan 2014
Demmers Martijn W H J, Baan Carla C, Janssen Malou, Litjens Nicolle H R, Ijzermans Jan N M, Betjes Michiel G, Weimar Willem, Rowshani Ajda T
Abstract excerpt
BACKGROUND: In spite of maintenance treatment with immunosuppressive drugs, tubulitis still occurs and can lead to structural kidney graft damage. We hypothesize that human renal tubular epithelial cells (TECs) trigger selective proliferation of recipient T-cell subsets with variable sensitivity to immunosuppressive drugs. METHODS: Recipient peripheral blood mononuclear cells were cocultured with donor-derived...
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