Article
SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering.
BMC bioinformatics - 23 Apr 2015
Van den Eynden Jimmy, Fierro Ana Carolina, Verbeke Lieven P C, Marchal Kathleen
Abstract excerpt
BACKGROUND: With the advances in high throughput technologies, increasing amounts of cancer somatic mutation data are being generated and made available. Only a small number of (driver) mutations occur in driver genes and are responsible for carcinogenesis, while the majority of (passenger) mutations do not influence tumour biology. In this study, SomInaClust is introduced, a method that accurately identifies...
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