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OncodriveROLE classifies cancer driver genes in loss of function and activating mode of action.

Bioinformatics (Oxford, England) - 1 Sept 2014

Schroeder Michael P, Rubio-Perez Carlota, Tamborero David, Gonzalez-Perez Abel, Lopez-Bigas Nuria

Abstract excerpt

MOTIVATION: Several computational methods have been developed to identify cancer drivers genes-genes responsible for cancer development upon specific alterations. These alterations can cause the loss of function (LoF) of the gene product, for instance, in tumor suppressors, or increase or change its activity or function, if it is an oncogene. Distinguishing between these two classes is important to understand...

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Identifiers

PMID: 25161246
DOI: 10.1093/bioinformatics/btu467
PMCID: PMC4147920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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