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Article

Targeting uPAR with Antagonistic Recombinant Human Antibodies in Aggressive Breast Cancer

11 Feb 2013

Abstract excerpt

Components of the plasminogen activation system, which are overexpressed in aggressive breast cancer subtypes, offer appealing targets for development of new diagnostics and therapeutics. By comparing gene expression data in patient populations and cultured cell lines, we identified elevated levels of the urokinase plasminogen activation receptor (uPAR, PLAUR) in highly aggressive breast cancer subtypes and cell...

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PMID: 23400595
DOI: 10.1158/0008-5472.can-12-3526

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