Article

Modeling the role of urokinase plasminogen activator, uPA, and circulating Cancer-Associated Fibroblasts (cCAFS) in breast cancer cell extravasation

2025-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Circulating Cancer-Associated Fibroblasts (cCAFs) have been discovered in circulating tumor cell clusters from all stages of disease progression in breast cancer patients. We have shown that CAFs promote lung metastases in the mouse tail vein model when they are clustered with triple negative breast cancer (TNBC) MDA-MB231 cells. Following on this observation, we saw that MDA-MB231-luciferase la...

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Literature Corpus work: 18132b21-0f4a-5334-8869-8a8c67bb91fe
DOI: 10.1101/2025.06.11.659108

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