Article
Role of HER2/neu in tumor progression and therapy.
Cellular and molecular life sciences : CMLS - 1 Dec 2004
Ménard S, Casalini P, Campiglio M, Pupa S M, Tagliabue E
Abstract excerpt
HER2 (human epidermal growth factor receptor-2; also known as erbB2) and its relatives HER1 (epidermal growth factor receptor; EGFR), HER3 and HER4 belong to the HER family of receptor tyrosine kinases. In normal cells, activation of this receptor tyrosine kinase family triggers a rich network of signaling pathways that control normal cell growth, differentiation, motility and adhesion in several cell lineages....
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