Article
Cerebral Cavernous Malformation: From Genetics to Pharmacotherapy.
Brain and behavior - 1 Jan 2025
Zhang Zhuangzhuang, Deng Jianwen, Sun Weiping, Wang Zhaoxia
Abstract excerpt
INTRODUCTION: Cerebral cavernous malformation (CCM) is a type of cerebrovascular abnormality in the central nervous system linked to both germline and somatic genetic mutations. Recent preclinical and clinical studies have shown that various drugs can effectively reduce the burden of CCM lesions. Despite significant progress, the mechanisms driving CCM remain incompletely understood, and to date, no drugs have...
Topics
- Humans
- Hemangioma, Cavernous, Central Nervous System
- Mutation
- Animals