Article
Uncovering Modifier Genes of X-Linked Alport Syndrome Using a Novel Multiparent Mouse Model.
Journal of the American Society of Nephrology : JASN - 1 Aug 2021
Takemon Yuka, Wright Valerie, Davenport Bernard, Gatti Daniel M, Sheehan Susan M, Letson Kelsey, Savage Holly S, Lennon Rachel, Korstanje Ron
Abstract excerpt
BACKGROUND: Mutations in COL4A5 are responsible for 80% of cases of X-linked Alport Syndrome (XLAS). Although genes that cause AS are well characterized, people with AS who have similar genetic mutations present with a wide variation in the extent of kidney impairment and age of onset, suggesting the activities of modifier genes. METHODS: We created a cohort of genetically diverse XLAS male and female mice using...
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