A Comparative Presentation of Mouse Models That Recapitulate Most Features of Alport Syndrome.

doi:10.3390/genes13101893

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Article

A Comparative Presentation of Mouse Models That Recapitulate Most Features of Alport Syndrome.

Genes - 18 Oct 2022

Nikolaou Stavros, Deltas Constantinos

Abstract excerpt

Alport syndrome is a hereditary kidney disease caused by mutations in the three genes encoding for collagen IV: COL4A3, COL4A4, and COL4A5. Several mouse models have been created for the study of this disease with variable phenotypic outcomes. This review is an up-to-date presentation of the current mouse models existing in the literature with a detailed comparison of the phenotypic features characterizing each...

Topics

Mice
Animals
Humans
Nephritis, Hereditary
Collagen Type IV
Disease Models, Animal
Mutation

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Open in PubMed Open full text

Identifiers

PMID: 36292778
DOI: 10.3390/genes13101893
PMCID: PMC9601682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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