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Article

Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort.

Arthritis and rheumatism - 1 Mar 2012

Plant Darren, Prajapati Rita, Hyrich Kimme L, Morgan Ann W, Wilson Anthony G, Isaacs John D, Barton Anne

Abstract excerpt

OBJECTIVE: Several rheumatoid arthritis (RA) susceptibility variants map close to genes involved in the tumor necrosis factor (TNF) signaling pathway, prompting the investigation of RA susceptibility variants in studies of predictors of response to TNF blockade. Based on a previously reported association of RA with the PTPRC genetic locus, the present study was undertaken to test established RA susceptibility...

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Identifiers

PMID: 21952740
DOI: 10.1002/art.33381
PMCID: PMC3427899

Genes

PTPRC
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort.PMID 21952740Read ↗

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