Article

Deep-sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas

2014-01-01

Abstract excerpt

Background: Molecular mechanisms associated with frequent relapse of diffuse large B-cell lymphoma (DLBCL) are poorly defined.It is especially unclear how primary tumor clonal heterogeneity contributes to relapse.Here, we explore unique features of B-cell lymphomas -VDJ recombination and somatic hypermutation -to address this question.Results: We performed high-throughput sequencing of rearranged VDJ junctions in...

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Literature Corpus work: 9cc81e88-0e3b-5709-a4b4-bc94d64a6c07
DOI: 10.1186/preaccept-6612547881370092

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