Article
Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas.
Genome biology - 15 Aug 2014
Jiang Yanwen, Redmond David, Nie Kui, Eng Ken W, Clozel Thomas, Martin Peter, Tan Leonard Hc, Melnick Ari M, Tam Wayne, Elemento Olivier
Abstract excerpt
BACKGROUND: Molecular mechanisms associated with frequent relapse of diffuse large B-cell lymphoma (DLBCL) are poorly defined. It is especially unclear how primary tumor clonal heterogeneity contributes to relapse. Here, we explore unique features of B-cell lymphomas - VDJ recombination and somatic hypermutation - to address this question. RESULTS: We performed high-throughput sequencing of rearranged VDJ...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.