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Article

Dissecting diffuse large B-cell lymphoma heterogeneity: New insights from a state-specific molecular characterisation.

Clinical and translational medicine - 1 Aug 2026

Papotti Robel, Vit Filippo, Bittolo Tamara, Pozzo Federico, Bettelli Stefania, Pozzi Samantha, Braglia Luca, Forti Elisa, Di Napoli Arianna, Cox M Christina, Tadmor Tamar, Musto Pellegrino, Flenghi Leonardo, Quintini Martina, Mansueto Giovanna R, Galimberti Sara, Donati Valentina, Spina Michele, Zamò Alberto, Rosenwald Andreas, Bomben Riccardo, Sacchi Stefano, Gattei Valter

Abstract excerpt

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease. METHODS: In this study, we analysed a real-world cohort of 178 newly diagnosed DLBCL patients homogeneously treated with R-CHOP-like regimens, integrating RNA sequencing, targeted mutational profiling and digital deconvolution using the EcoTyper algorithm. RESULTS: Five malignant B-cell states (S1-S5) were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42613996
DOI: 10.1002/ctm2.70757
PMCID: PMC13487464

Genes

ACTB
CD79B
CREBBP
MYD88
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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