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CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women.

Arthritis research & therapy - 11 Mar 2015

Stark Klaus, Straub Rainer H, Rovenský Jozef, Blažičková Stanislava, Eiselt Gabriele, Schmidt Martin

Abstract excerpt

INTRODUCTION: Rheumatoid arthritis (RA) is characterized by decreased androgen levels, which was the first hormonal abnormality described. Several studies indicated that steroidogenesis is directed towards endogenous glucocorticoids at the expense of androgens. The decisive step governing androgen synthesis is the 17,20-lyase activity of the CYP17A1 gene-encoded enzyme cytochrome P450 17A1. Here, we focused on...

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Identifiers

PMID: 25890314
DOI: 10.1186/s13075-015-0574-9
PMCID: PMC4372052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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