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Article

Role of SLC22A4, SLC22A5, and RUNX1 genes in rheumatoid arthritis.

The Journal of rheumatology - 1 May 2006

Martínez Alfonso, Valdivia Antonio, Pascual-Salcedo Dora, Balsa Alejandro, Fernández-Gutiérrez Benjamín, De la Concha Emilio, Urcelay Elena

Abstract excerpt

OBJECTIVE: Excessively suppressed expression of the SLC22A4 gene by RUNX1 is associated with the pathogenesis of rheumatoid arthritis (RA). Two etiological polymorphisms in the RUNX1 and SLC22A4 genes have been defined in a Japanese population. We studied additional polymorphisms to ascertain whether any SLC22A4/SLC22A5 haplotype is relevant for RA predisposition in a Spanish population. METHOD: We performed a...

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Source

Identifiers

PMID: 16652416

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of SLC22A4, SLC22A5, and RUNX1 genes in rheumatoid arthritis.PMID 16652416Read ↗

Meta-analysis of SLC22A4 and RUNX1 polymorphisms : Associations with rheumatoid arthritis susceptibility.Semantic proximity Read ↗

SLC22A4, RUNX1, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: a case-control study in a Spanish population.Semantic proximity Read ↗

SLC22A4 and RUNX1: identification of RA susceptible genes.Semantic proximity Read ↗

An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.Semantic proximity Read ↗

SLC22A4 polymorphism and rheumatoid arthritis susceptibility: a replication study in a Japanese population and a metaanalysis.Semantic proximity Read ↗

Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus.Semantic proximity Read ↗

Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies.Semantic proximity Read ↗

Association of SLC22A4 gene polymorphism with Rheumatoid arthritis in the Chinese population.Semantic proximity Read ↗

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Association of joint erosion with SLC22A4 gene polymorphisms inconsistently associated with rheumatoid arthritis susceptibility.Semantic proximity Read ↗

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A haplotype in STAT4 gene associated with rheumatoid arthritis in Caucasians is not associated in the Han Chinese population, but with the presence of rheumatoid factor.Semantic proximity Read ↗

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