Article
Association of CD4 enhancer gene polymorphisms with rheumatoid arthritis in Egyptian female patients.
Rheumatology international - 1 Aug 2012
Hussein Yousri M, El Tarhouny Shereen A, Mohamed Randa H, El-Shal Amal S, Abul-Saoud Amany M, Abdo Manal
Abstract excerpt
CD4 is a candidate gene in autoimmune diseases, including rheumatoid arthritis (RA). Because the CD4 receptor is crucial for appropriate antigen responses of CD4+ T cells, changes in CD4 expression and CD4+ T-cell activity may influence tolerance or tissue destruction in autoimmune diseases and contribute to their risk. We analyzed two polymorphisms of the CD4 in 172 female Egyptian patients with RA and in 112...
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