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Article

Lack of association between CYB5A gene rs1790834 polymorphism and the response to leflunomide in women with rheumatoid arthritis.

European journal of clinical pharmacology - 1 Nov 2021

Łączna Małgorzata, Malinowski Damian, Paradowska-Gorycka Agnieszka, Safranow Krzysztof, Dziedziejko Violetta, Pawlik Andrzej

Abstract excerpt

AIM: Leflunomide is a disease-modifying antirheumatic drug used in therapy for rheumatoid arthritis (RA). Previous studies indicated that oestrogens and androgens may affect the response to leflunomide in RA patients. The synthesis of androgens is regulated by cytochrome CYB5A. The aim of this study was to examine the association between the CYB5A gene rs1790834 polymorphism and the response to leflunomide in...

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Identifiers

PMID: 34160668
DOI: 10.1007/s00228-021-03172-3
PMCID: PMC8528780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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