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Article

Testing the balanced electrostatic interaction hypothesis of hepatitis B virus DNA synthesis by using an in vivo charge rebalance approach.

Journal of virology - 1 Mar 2010

Chua Pong Kian, Tang Fan-Mei, Huang Jyuan-Yuan, Suen Ching-Shu, Shih Chiaho

Abstract excerpt

Previously, a charge balance hypothesis was proposed to explain hepatitis B virus (HBV) capsid stability, assembly, RNA encapsidation, and DNA replication. This hypothesis emphasized the importance of a balanced electrostatic interaction between the positive charge from the arginine-rich domain (ARD) of the core protein (HBc) and the negative charge from the encapsidated nucleic acid. It remains unclear if any of...

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Identifiers

PMID: 20015989
DOI: 10.1128/JVI.01666-09
PMCID: PMC2820918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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