Article
Exome sequencing of a family with lone, autosomal dominant atrial flutter identifies a rare variation in ABCB4 significantly enriched in cases.
BMC genetics - 11 Feb 2015
Maciąg Anna, Villa Francesco, Ferrario Anna, Spinelli Chiara Carmela, Carrizzo Albino, Malovini Alberto, Torella Annalaura, Montenero Chiara, Parisi Attilio, Condorelli Gianluigi, Vecchione Carmine, Nigro Vincenzo, Montenero Annibale Sandro, Puca Annibale Alessandro
Abstract excerpt
BACKGROUND: Lone atrial flutter (AFL) and atrial fibrillation (AF) are common and sometimes consequential cardiac conduction disorders with a strong heritability, as underlined by recent genome-wide association studies that identified genetic modifiers. Follow-up family-based genetic analysis also identified Mendelian transmission of disease alleles. Three affected members were exome-sequenced for the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.