Article
Genetic testing in monogenic early-onset atrial fibrillation.
European journal of human genetics : EJHG - 1 Jul 2023
Chalazan Brandon, Freeth Emma, Mohajeri Arezoo, Ramanathan Krishnan, Bennett Matthew, Walia Jagdeep, Halperin Laura, Roston Thomas, Lazarte Julieta, Hegele Robert A, Lehman Anna, Laksman Zachary
Abstract excerpt
A substantial proportion of atrial fibrillation (AF) cases cannot be explained by acquired AF risk factors. Limited guidelines exist that support routine genetic testing. We aim to determine the prevalence of likely pathogenic and pathogenic variants from AF genes with robust evidence in a well phenotyped early-onset AF population. We performed whole exome sequencing on 200 early-onset AF patients. Variants from...
Topics
- Humans
- Male
- Adult
- Middle Aged
- Female
- Atrial Fibrillation
- Genetic Testing
- Risk Factors
- Phenotype
- Polymorphism, Single Nucleotide
- Genetic Predisposition to Disease