Article
Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies.
BMC genomics - 10 Mar 2015
Levine Adam P, Connor Thomas M F, Oygar D Deren, Neild Guy H, Segal Anthony W, Maxwell Patrick H, Gale Daniel P
Abstract excerpt
BACKGROUND: The ability to identify regions of the genome inherited with a dominant trait in one or more families has become increasingly valuable with the wide availability of high throughput sequencing technology. While a number of methods exist for mapping of homozygous variants segregating with recessive traits in consanguineous families, dominant conditions are conventionally analysed by linkage analysis,...
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