Article
An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis.
Critical care (London, England) - 5 Mar 2015
Cui Lili, Gao Yan, Xie Yuliu, Wang Yan, Cai Yujie, Shao Xin, Ma Xiaotang, Li You, Ma Guoda, Liu Gen, Cheng Wanwen, Liu Yu, Liu Tingting, Pan Qunwen, Tao Hua, Liu Zhou, Zhao Bin, Shao Yiming, Li Keshen
Abstract excerpt
INTRODUCTION: Although genetic variants of the A disintegrin and metalloproteinase 10 (ADAM10) gene have been shown to be associated with susceptibility to several inflammatory-related diseases, to date little is known about the clinical relationship in the development of sepsis. METHODS: Two genetic variants in the promoter of ADAM10 were selected to analyze the potential association with the risk of sepsis. A...
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