Article
The -172 A-to-G variation in ADAM17 gene promoter region affects EGR1/ADAM17 pathway and confers susceptibility to septic mortality with sepsis-3.0 criteria.
International immunopharmacology - 1 Jan 2022
He Junbing, Zhao Tian, Liu Lizhen, Liao Shuanglin, Yang Shuai, Lu Furong, Hong Yuan, Wei Ning, Cheng Hongxiao, Zhang Wenying, Shao Yiming
Abstract excerpt
BACKGROUND: A disintegrin and metalloproteinase 17 (ADAM17) is a proteolytic cleaving protein with a crucial function in the inflammatory responses, especially sepsis. But the clear role of ADAM17 in sepsis and the underlying mechanism remained unknown. In this study, we aim to determine the clinical association of ADAM17 -172A > G (rs12692386) promoter polymorphism with sepsis and to further explore the effect...
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