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The -172A>G polymorphism in ADAM17 promoter region enhances its binding to EGR1 and confers susceptibility to sepsis progression

2021-01-11

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> A disintegrin and metalloproteinase 17 (ADAM17) is a proteolytic cleaving protein with a crucial function in inflammatory responses, especially sepsis. But the clear role of ADAM17 in sepsis and the underlying mechanism remained unknown. In this study, we aim to determine the clinical relevance of the ADAM17 rs12692386 (-172A>G) promoter polymorphism in sepsis p...

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Literature Corpus work
00d633ea-1648-5449-b859-6f9df6c7556e
DOI
10.21203/rs.3.rs-73158/v2
Open publication

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