Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Functional Polymorphism-Mediated Disruption of EGR1/ADAM10 Pathway Confers the Risk of Sepsis Progression

5 Aug 2019

Abstract excerpt

Sepsis is characterized as life-threatening organ dysfunction, with unacceptably high mortality. Evidence has indicated that functional SNPs within inflammatory genes are associated with susceptibility, progression, and prognosis of sepsis. These mechanisms on which these susceptible sites depended often suggest the key pathogenesis and potential targets in sepsis. In the present study, we confirmed that a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to Sepsis Diagnosis and Treatment
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31387910
DOI: 10.1128/mbio.01663-19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Functional Polymorphism-Mediated Disruption of EGR1/ADAM10 Pathway Confers the Risk of Sepsis ProgressionPMID 31387910Read ↗

The -172 A-to-G variation in ADAM17 gene promoter region affects EGR1/ADAM17 pathway and confers susceptibility to septic mortality with sepsis-3.0 criteria.Semantic proximity Read ↗

The -172A>G polymorphism in ADAM17 promoter region enhances its binding to EGR1 and confers susceptibility to sepsis progressionSemantic proximity Read ↗

An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis.Semantic proximity Read ↗

Genetic polymorphisms and sepsis.Semantic proximity Read ↗

Genetic insights into sepsis: what have we learned and how will it help?Semantic proximity Read ↗

Genomic polymorphisms in sepsisSemantic proximity Read ↗

Host genetic variants in sepsis risk: a field synopsis and meta-analysisSemantic proximity Read ↗

Association Study Between Promoter Polymorphisms of ADAM17 and Progression of Sepsis.Semantic proximity Read ↗

Genetic polymorphisms in sepsis.Semantic proximity Read ↗

Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy.Semantic proximity Read ↗

Bench-to-bedside review: understanding genetic predisposition to sepsis.Semantic proximity Read ↗

Association Between IL10 Polymorphisms and the Susceptibility to Sepsis: A Meta-Analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.