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Article

Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa.

PloS one - 1 Jan 2013

Müller Borna, Chihota Violet N, Pillay Manormoney, Klopper Marisa, Streicher Elizabeth M, Coetzee Gerrit, Trollip Andre, Hayes Cindy, Bosman Marlein E, Gey van Pittius Nicolaas C, Victor Thomas C, Gagneux Sebastien, van Helden Paul D, Warren Robin M

Abstract excerpt

BACKGROUND: South Africa shows one of the highest global burdens of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Since 2002, MDR-TB in South Africa has been treated by a standardized combination therapy, which until 2010 included ofloxacin, kanamycin, ethionamide, ethambutol and pyrazinamide. Since 2010, ethambutol has been replaced by cycloserine or terizidone. The effect of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24058399
DOI: 10.1371/journal.pone.0070919
PMCID: PMC3751934

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Source receipt: pubmed, retrieved 7 Sept 2026.

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