Article
Transmission, distribution and drug resistance-conferring mutations of extensively drug-resistant tuberculosis in the Western Cape Province, South Africa.
Microbial genomics - 1 Apr 2022
Oostvogels Selien, Ley Serej D, Heupink Tim H, Dippenaar Anzaan, Streicher Elizabeth M, De Vos Elise, Meehan Conor J, Dheda Keertan, Warren Rob, Van Rie Annelies
Abstract excerpt
Extensively drug-resistant tuberculosis (XDR-TB), defined as resistance to at least isoniazid (INH), rifampicin (RIF), a fluoroquinolone (FQ) and a second-line injectable drug (SLID), is difficult to treat and poses a major threat to TB control. The transmission dynamics and distribution of XDR Mycobacterium tuberculosis (Mtb) strains have not been thoroughly investigated. Using whole genome sequencing data on...
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